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Article

Genetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia.

Scientific reports - 16 May 2017

Pavel Ana B, Korolev Kirill S

Abstract excerpt

Genetic alterations initiate tumors and enable the evolution of drug resistance. The pro-cancer view of mutations is however incomplete, and several studies show that mutational load can reduce tumor fitness. Given its negative effect, genetic load should make tumors more sensitive to anticancer drugs. Here, we test this hypothesis across all major types of cancer from the Cancer Cell Line Encyclopedia, which...

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Antineoplastic Agents
Cell Line, Tumor
DNA Copy Number Variations
Drug Resistance, Neoplasm
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28512298
DOI: 10.1038/s41598-017-02178-1
PMCID: PMC5434051

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