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Article

Systematic pan-cancer analysis of mutation-treatment interactions using large real-world clinicogenomics data.

Nature medicine - 1 Aug 2022

Liu Ruishan, Rizzo Shemra, Waliany Sarah, Garmhausen Marius Rene, Pal Navdeep, Huang Zhi, Chaudhary Nayan, Wang Lisa, Harbron Chris, Neal Joel, Copping Ryan, Zou James

Abstract excerpt

Quantifying the effectiveness of different cancer therapies in patients with specific tumor mutations is critical for improving patient outcomes and advancing precision medicine. Here we perform a large-scale computational analysis of 40,903 US patients with cancer who have detailed mutation profiles, treatment sequences and outcomes derived from electronic health records. We systematically identify 458 mutations...

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PMID: 35773542
DOI: 10.1038/s41591-022-01873-5

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