Article
Emerging landscape of oncogenic signatures across human cancers.
Nature genetics - 1 Oct 2013
Ciriello Giovanni, Miller Martin L, Aksoy Bülent Arman, Senbabaoglu Yasin, Schultz Nikolaus, Sander Chris
Abstract excerpt
Cancer therapy is challenged by the diversity of molecular implementations of oncogenic processes and by the resulting variation in therapeutic responses. Projects such as The Cancer Genome Atlas (TCGA) provide molecular tumor maps in unprecedented detail. The interpretation of these maps remains a major challenge. Here we distilled thousands of genetic and epigenetic features altered in cancers to ∼500 selected...
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