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Article

Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells

11 Jul 2016

Abstract excerpt

The precise identity of a tumour's cell of origin can influence disease prognosis and outcome. Methods to reliably define tumour cell of origin from primary, bulk tumour cell samples has been a challenge. Here we use a well-defined model of MLL-rearranged acute myeloid leukaemia (AML) to demonstrate that transforming haematopoietic stem cells (HSCs) and multipotent progenitors results in more aggressive AML than...

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PMID: 27397025
DOI: 10.1038/ncomms12166

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