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Article

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.

PloS one - 1 Jan 2016

Rulifson Ingrid C, Cao Ping, Miao Li, Kopecky David, Huang Linda, White Ryan D, Samayoa Kim, Gardner Jonitha, Wu Xiaosu, Chen Kui, Tsuruda Trace, Homann Oliver, Baribault Helene, Yamane Harvey, Carlson Tim, Wiltzius Jed, Li Yang

Abstract excerpt

Pancreatic amyloid formation by islet amyloid polypeptide (IAPP) is a hallmark pathological feature of type 2 diabetes. IAPP is stored in the secretory granules of pancreatic beta-cells and co-secreted with insulin to maintain glucose homeostasis. IAPP is innocuous under homeostatic conditions but imbalances in production or processing of IAPP may result in homodimer formation leading to the rapid production of...

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Share to Amyloid Precursor Protein Secretases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Insulin-Secreting Cells

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Source

Open in PubMed Open full text

Identifiers

PMID: 26840340
DOI: 10.1371/journal.pone.0147254
PMCID: PMC4739698

Genes

IAPP
BACE2
APP
BACE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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