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Article

CHOP Contributes to, But Is Not the Only Mediator of, IAPP Induced β-Cell Apoptosis

22 Feb 2016

Abstract excerpt

The islet in type 2 diabetes is characterized by β-cell loss, increased β-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). When protein misfolding protective mechanisms are overcome, human IAPP (h-IAPP) forms membrane permeant toxic oligomers that induce β-cell dysfunction and apoptosis. In humans with type 2 diabetes (T2D) and mice transgenic for h-IAPP, endoplasmic reticulum (ER)...

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PMID: 26900721
DOI: 10.1210/me.2015-1255

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