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Article

The genetic background influences the cellular and humoral immune responses to vaccines.

Clinical and experimental immunology - 1 Nov 2016

Zeng M, Nourishirazi E, Guinet E, Nouri-Shirazi M

Abstract excerpt

The assessment of Toll-like receptor (TLR) agonists as candidate adjuvants for induction of effective T helper type 1 (Th1) immunity continues to rely on the use of mice. However, the genetic variation among inbred mice may influence the efficacy of adjuvants and bias a study's conclusions. Here, we evaluated the differences in cellular and humoral responses of genetically non-identical mouse strains immunized...

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Identifiers

PMID: 27393001
DOI: 10.1111/cei.12841
PMCID: PMC5054571

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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