The genetic background influences the cellular and humoral immune responses to vaccines.

doi:10.1111/cei.12841

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Article

The genetic background influences the cellular and humoral immune responses to vaccines.

Clinical and experimental immunology - 1 Nov 2016

Zeng M, Nourishirazi E, Guinet E, Nouri-Shirazi M

Abstract excerpt

The assessment of Toll-like receptor (TLR) agonists as candidate adjuvants for induction of effective T helper type 1 (Th1) immunity continues to rely on the use of mice. However, the genetic variation among inbred mice may influence the efficacy of adjuvants and bias a study's conclusions. Here, we evaluated the differences in cellular and humoral responses of genetically non-identical mouse strains immunized...

Topics

Animals
Antibodies
Antigens
Biomarkers
Chemotaxis, Leukocyte
Cytokines
Dendritic Cells
Genetic Association Studies
Genetic Background
Immunity, Cellular
Immunity, Humoral
Killer Cells, Natural
Lymphocytes
Male
Mice
Mice, Inbred BALB C
Phenotype
Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 27393001
DOI: 10.1111/cei.12841
PMCID: PMC5054571

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