Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice.

Veterinary pathology - 1 Jan 2012

Sellers R S, Clifford C B, Treuting P M, Brayton C

Abstract excerpt

Inbred laboratory mouse strains are highly divergent in their immune response patterns as a result of genetic mutations and polymorphisms. The generation of genetically engineered mice (GEM) has, in the past, used embryonic stem (ES) cells for gene targeting from various 129 substrains followed by backcrossing into more fecund mouse strains. Although common inbred mice are considered "immune competent," many have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Engineering
Share to Mice
Share to Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Models, Animal

Share to Mutation

Share to Phenotype

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 22135019
DOI: 10.1177/0300985811429314

Genes

GEM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice.PMID 22135019Read ↗

Wild-derived mice: from genetic diversity to variation in immune responses.Semantic proximity Read ↗

Genetic influence on immune phenotype revealed strain-specific variations in peripheral blood lineages.Semantic proximity Read ↗

Microbial considerations in genetically engineered mouse research.Semantic proximity Read ↗

Congenic mice: cutting tools for complex immune disorders.Semantic proximity Read ↗

Naturalizing mouse models for immunology.Semantic proximity Read ↗

Normalizing the environment recapitulates adult human immune traits in laboratory mice.Semantic proximity Read ↗

Effects of different environments and microbial exposures on the adult immune system of the C57BL/6 laboratory mouse strainSemantic proximity Read ↗

Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.Semantic proximity Read ↗

Variations in the germinal center response revealed by genetically diverse mouse strains.Semantic proximity Read ↗

Phenotypic characteristics of commonly used inbred mouse strains.Semantic proximity Read ↗

Leishmania major infection of inbred mice: unmasking genetic determinants of infectious diseases.Semantic proximity Read ↗

New tools for defining the 'genetic background' of inbred mouse strains.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.