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Article

CNS germinomas are characterized by global demethylation, chromosomal instability and mutational activation of the Kit-, Ras/Raf/Erk- and Akt-pathways.

Oncotarget - 23 Aug 2016

Schulte Simone Laura, Waha Andreas, Steiger Barbara, Denkhaus Dorota, Dörner Evelyn, Calaminus Gabriele, Leuschner Ivo, Pietsch Torsten

Abstract excerpt

CNS germinomas represent a unique germ cell tumor entity characterized by undifferentiated tumor cells and a high response rate to current treatment protocols. Limited information is available on their underlying genomic, epigenetic and biological alterations. We performed a genome-wide analysis of genomic copy number alterations in 49 CNS germinomas by molecular inversion profiling. In addition, CpG dinucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27391150
DOI: 10.18632/oncotarget.10392
PMCID: PMC5342399

Genes

KIT
KRAS
NRAS
RRAS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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