Article
Genome-wide methylation profiles in primary intracranial germ cell tumors indicate a primordial germ cell origin for germinomas.
Acta neuropathologica - 1 Mar 2017
Fukushima Shintaro, Yamashita Satoshi, Kobayashi Hisato, Takami Hirokazu, Fukuoka Kohei, Nakamura Taishi, Yamasaki Kai, Matsushita Yuko, Nakamura Hiromi, Totoki Yasushi, Kato Mamoru, Suzuki Tomonari, Mishima Kazuhiko, Yanagisawa Takaaki, Mukasa Akitake, Saito Nobuhito, Kanamori Masayuki, Kumabe Toshihiro, Tominaga Teiji, Nagane Motoo, Iuchi Toshihiko, Yoshimoto Koji, Mizoguchi Masahiro, Tamura Kaoru, Sakai Keiichi, Sugiyama Kazuhiko, Nakada Mitsutoshi, Yokogami Kiyotaka, Takeshima Hideo, Kanemura Yonehiro, Matsuda Masahide, Matsumura Akira, Kurozumi Kazuhiko, Ueki Keisuke, Nonaka Masahiro, Asai Akio, Kawahara Nobutaka, Hirose Yuichi, Takayama Tatusya, Nakazato Yoichi, Narita Yoshitaka, Shibata Tatsuhiro, Matsutani Masao, Ushijima Toshikazu, Nishikawa Ryo, Ichimura Koichi
Abstract excerpt
Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conventionally subclassified into pure germinoma or non-germinomatous GCTs. Recent exhaustive genomic studies showed that mutations of the genes involved in the MAPK and/or PI3K pathways are common in iGCTs;...
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