Article
Recurrent neomorphic mutations of MTOR in central nervous system and testicular germ cell tumors may be targeted for therapy.
Acta neuropathologica - 1 Jun 2016
Ichimura Koichi, Fukushima Shintaro, Totoki Yasushi, Matsushita Yuko, Otsuka Ayaka, Tomiyama Arata, Niwa Tohru, Takami Hirokazu, Nakamura Taishi, Suzuki Tomonari, Fukuoka Kohei, Yanagisawa Takaaki, Mishima Kazuhiko, Nakazato Yoichi, Hosoda Fumie, Narita Yoshitaka, Shibui Soichiro, Yoshida Akihiko, Mukasa Akitake, Saito Nobuhito, Kumabe Toshihiro, Kanamori Masayuki, Tominaga Teiji, Kobayashi Keiichi, Shimizu Saki, Nagane Motoo, Iuchi Toshihiko, Mizoguchi Masahiro, Yoshimoto Koji, Tamura Kaoru, Maehara Taketoshi, Sugiyama Kazuhiko, Nakada Mitsutoshi, Sakai Keiichi, Kanemura Yonehiro, Nonaka Masahiro, Asai Akio, Yokogami Kiyotaka, Takeshima Hideo, Kawahara Nobutaka, Takayama Tatsuya, Yao Masahiro, Kato Mamoru, Nakamura Hiromi, Hama Natsuko, Sakai Ryuichi, Ushijima Toshikazu, Matsutani Masao, Shibata Tatsuhiro, Nishikawa Ryo
Abstract excerpt
Germ cell tumors constitute a heterogeneous group that displays a broad spectrum of morphology. They often arise in testes; however, extragonadal occurrence, in particular brain, is not uncommon, and whether they share a common pathogenesis is unknown. We performed whole exome sequencing in 41 pairs of central nervous system germ cell tumors (CNS GCTs) of various histology and their matched normal tissues. We...
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