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Article

Novel molecular subtypes of intracranial germ cell tumors expand therapeutic opportunities.

Neuro-oncology - 5 Jul 2024

Li Bo, Zhao Shuang, Li Shouwei, Li Chunde, Liu Wei, Li Lin, Cui Bowen, Liu Xing, Chen Huiyuan, Zhang Jing, Ren Yin, Liu Fei, Yang Ming, Jiang Tao, Liu Yu, Qiu Xiaoguang

Abstract excerpt

BACKGROUND: Intracranial germ cell tumors (IGCTs) are a rare group of malignancies that are clinically classified as germinomas and nongerminomatous germ cell tumors (NGGCTs). Previous studies have found that somatic mutations involving the mitogen-activated protein kinase/mTOR signaling pathway are common early events. However, a comprehensive genomic understanding of IGCTs is still lacking. METHODS: We...

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Identifiers

PMID: 38430549
DOI: 10.1093/neuonc/noae038
PMCID: PMC11226877

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