Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts.

doi:10.1093/neuonc/noac021

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Transcriptome and methylome analysis of CNS germ cell tumor finds its cell-of-origin in embryogenesis and reveals shared similarities with testicular counterparts.

Neuro-oncology - 1 Aug 2022

Takami Hirokazu, Elzawahry Asmaa, Mamatjan Yasin, Fukushima Shintaro, Fukuoka Kohei, Suzuki Tomonari, Yanagisawa Takaaki, Matsushita Yuko, Nakamura Taishi, Satomi Kaishi, Tanaka Shota, Mukasa Akitake, Saito Nobuhito, Kanamori Masayuki, Kumabe Toshihiro, Tominaga Teiji, Kobayashi Keiichi, Nagane Motoo, Iuchi Toshihiko, Tamura Kaoru, Maehara Taketoshi, Sugiyama Kazuhiko, Yoshimoto Koji, Sakai Keiichi, Nonaka Masahiro, Asai Akio, Yokogami Kiyotaka, Takeshima Hideo, Narita Yoshitaka, Shibui Soichiro, Nakazato Yoichi, Hama Natsuko, Totoki Yasushi, Kato Mamoru, Shibata Tatsuhiro, Nishikawa Ryo, Matsutani Masao, Ichimura Koichi

Abstract excerpt

BACKGROUND: CNS germ cell tumors (GCTs) predominantly develop in pediatric and young adult patients with variable responses to surgery, radiation, and chemotherapy. This study aimed to examine the complex and largely unknown pathogenesis of CNS GCTs. METHODS: We used a combined transcriptomic and methylomic approach in 84 cases and conducted an integrative analysis of the normal cells undergoing embryogenesis and...

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Identifiers

PMID: 35137206
DOI: 10.1093/neuonc/noac021
PMCID: PMC9340652

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Source receipt: pubmed, retrieved 7 Sept 2026.

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