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Advances in genetic abnormalities, epigenetic reprogramming, and immune landscape of intracranial germ cell tumors

27 Nov 2023

Abstract excerpt

Intracranial germ cell tumors (IGCTs) are a rare subtype of central nervous system neoplasms that predominantly affect young individuals and exhibit a higher incidence in East Asia. IGCTs can be pathologically divided into two main categories: germinomas and non-germinomatous germ cell tumors (NGGCTs). Despite the scarcity of this disease, recent advancements in molecular biology techniques have facilitated the...

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PMID: 38012690
DOI: 10.1186/s40478-023-01682-y

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