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Article

Novel ERα positive breast cancer model with estrogen independent growth in the bone microenvironment.

Oncotarget - 2 Aug 2016

Capietto Aude-Hélène, Chan Szeman Ruby, Ricci Biancamaria, Allen Julie A, Su Xinming, Novack Deborah V, Schreiber Robert D, Faccio Roberta

Abstract excerpt

Despite successful therapeutic options for estrogen receptor-α (ERα)+ breast cancer, resistance to endocrine therapy frequently occurs leading to tumor recurrence. In addition to intrinsic changes in the cancer cells, herein we demonstrate that tumor cell-microenvironment interactions can drive recurrence at specific sites. By using two ERα+ cell lines derived from spontaneous mammary carcinomas in STAT1-/- mice...

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Share to Antineoplastic Agents, Hormonal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

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Share to Receptors, Progesterone

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Source

Open in PubMed Open full text

Identifiers

PMID: 27391074
DOI: 10.18632/oncotarget.10443
PMCID: PMC5226545

Genes

JAK2
STAT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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