Article

Phenotypic plasticity of ER+ breast cancer in the bone microenvironment

2020-11-15

Abstract excerpt

<h4>Summary</h4> ER+ breast cancer exhibits a strong bone-tropism in metastasis. How the bone microenvironment impacts the ER signaling and endocrine therapies remains poorly understood. Here, we discover that the osteogenic niche transiently reduces ER expression and activities specifically in bone micrometastases (BMMs), leading to endocrine resistance. This is mediated by gap junctions and paracrine FGF/PDGF s...

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Literature Corpus work: be250c60-d341-53b0-9d10-48cb399c83ff
DOI: 10.1101/2020.11.14.383000

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