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Article

Point-activated ESR1Y541S has a dramatic effect on the development of sexually dimorphic organs.

Genes & development - 1 Oct 2020

Simond Alexandra M, Ling Chen, Moore Michaela J, Condotta Stephanie A, Richer Martin J, Muller William J

Abstract excerpt

Mutations in the estrogen receptor α (ERα) occur in endocrine-resistant metastatic breast cancer. However, a major gap persists with the lack of genetically tractable immune competent mouse models to study disease. Hence, we developed a Cre-inducible murine model expressing a point-activated ESR1Y541S (ESR1Y537S in humans) driven by its endogenous promoter. Germline expression of mutant ESR1Y541S reveals dramatic...

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Identifiers

PMID: 32912899
DOI: 10.1101/gad.339424.120
PMCID: PMC7528702

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