Back to search

Article

A Novel Model of Estrogen Receptor-Positive Breast Cancer Bone Metastasis with Antiestrogen Responsiveness

2021-09-17

Abstract excerpt

Most women diagnosed with breast cancer (BC) have estrogen receptor alpha positive (ER+) disease. ER+ BC preferentially metastasizes to bone; at which time it is considered incurable. Treatments for bone metastasis have not advanced in decades, in part due to a lack of appropriate ER+ BC bone metastasis models. We developed an immunocompetent ER+ BC murine model with spontaneous bone metastasis and antiestrogen re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9e81ca03-724d-5c70-8aab-e298ebb684be
DOI
10.1101/2021.09.16.460665
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Novel Model of Estrogen Receptor-Positive Breast Cancer Bone Metastasis with Antiestrogen ResponsivenessDOI 10.1101/2021.09.16.460665
An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer.Semantic proximity
The EO771 mammary cancer cell line displays a luminal B phenotype and it is sensitive to anti-estrogen treatmentsSemantic proximity
Estrogen receptors and extracellular matrix: the critical interplay in cancer development and progressionSemantic proximity
Novel ERα positive breast cancer model with estrogen independent growth in the bone microenvironment.Semantic proximity
Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodelingSemantic proximity
Functional and molecular characterisation of EO771.LMB tumours, a new C57BL/6-mouse-derived model of spontaneously metastatic mammary cancer.Semantic proximity
Epithelial-mesenchymal plasticity determines estrogen receptor positive (ER+) breast cancer dormancy and reacquisition of an epithelial state drives awakeningSemantic proximity
Overview of the therapeutic strategies for ER positive breast cancer.Semantic proximity
Estrogen receptor-positive cell line xenograft models recapitulate metastatic dissemination and endocrine response of invasive lobular breast carcinomaSemantic proximity
Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicineSemantic proximity
Regulation of breast cancer metastasis by Runx2 and estrogen signaling: the role of SNAI2Semantic proximity
Integrins Alpha-2 and Beta-1 expression increases through Multiple Generations of the EDW01 Patient-Derived Xenograft Model of Breast Cancer - insight into their role in Epithelial Mesenchymal Transition in vivo gained from an in vitro model systemSemantic proximity
Select a neighboring publication to make it the new centre.