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Dynamic bioinspired coculture model for probing ER + breast cancer dormancy in the bone marrow niche

8 Mar 2023

Abstract excerpt

Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells (DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor–positive (ER + ) breast cancer cells (BCCs) in bone marrow (BM). Interactions between the BM niche and BCCs are thought to play a pivotal role in recurrence, and relevant model systems are needed for mechanistic insights and improved...

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PMID: 36888709
DOI: 10.1126/sciadv.ade3186

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