Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice.

Molecular cancer - 6 Jan 2012

Marshall Aaron M, McClaine Rebecca J, Gurusamy Devikala, Gray Jerilyn K, Lewnard Kara E, Khan Sohaib A, Waltz Susan E

Abstract excerpt

BACKGROUND: The receptor tyrosine kinase family includes many transmembrane proteins with diverse physiological and pathophysiological functions. The involvement of tyrosine kinase signaling in promoting a more aggressive tumor phenotype within the context of chemotherapeutic evasion is gaining recognition. The Ron receptor is a tyrosine kinase receptor that has been implicated in the progression of breast cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Proliferation
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Mammary Neoplasms, Animal

Share to Mice, Nude

Share to Neoplasm Metastasis

Share to Neoplasm Staging

Share to Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 22226043
DOI: 10.1186/1476-4598-11-2
PMCID: PMC3286430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice.PMID 22226043Read ↗

Oncogenesis of RON receptor tyrosine kinase: a molecular target for malignant epithelial cancers.Semantic proximity Read ↗

The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancerSemantic proximity Read ↗

Modulation of estrogen receptor alpha activity and expression during breast cancer progression.Semantic proximity Read ↗

Overexpression of the RON gene in human breast carcinomaSemantic proximity Read ↗

An Introduction and Overview of RON Receptor Tyrosine Kinase SignalingSemantic proximity Read ↗

Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic diseaseSemantic proximity Read ↗

Estrogen-Related Receptor α Is Critical for the Growth of Estrogen Receptor–Negative Breast CancerSemantic proximity Read ↗

Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis.Semantic proximity Read ↗

Oncogenic variant RON160 expression in breast cancer and its potential as a therapeutic target by small molecule tyrosine kinase inhibitor.Semantic proximity Read ↗

RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.Semantic proximity Read ↗

Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential.Semantic proximity Read ↗

A Novel Model of Estrogen Receptor-Positive Breast Cancer Bone Metastasis with Antiestrogen ResponsivenessSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.