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Article

BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice.

Journal of cellular physiology - 1 Dec 2020

Ieraci Alessandro, Barbieri Silvia S, Macchi Chiara, Amadio Patrizia, Sandrini Leonardo, Magni Paolo, Popoli Maurizio, Ruscica Massimiliano

Abstract excerpt

Obesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain-derived neurotrophic factor (BDNF) Val66Met single-nucleotide polymorphism (SNP) and obesity, although the underlying...

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PMID: 32430940
DOI: 10.1002/jcp.29778

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