Article
CD1d expression on chronic lymphocytic leukemia B cells affects disease progression and induces T cell skewing in CD8 positive and CD4CD8 double negative T cells.
Oncotarget - 2 Aug 2016
Zaborsky Nadja, Gassner Franz Josef, Asslaber Daniela, Reinthaler Petra, Denk Ursula, Flenady Sabine, Hofbauer Josefina Piñón, Danner Barbara, Rebhandl Stefan, Harrer Andrea, Geisberger Roland, Greil Richard, Egle Alexander
Abstract excerpt
Chronic lymphocytic leukemia develops within a complex network driven by genetic mutations and microenvironmental interactions. Among the latter a complex interplay with the immune system is established by the clone. Next to a proposed recruitment of support from T and myeloid cells, potential anti-CLL immune reactions need to be subverted. By using TCL1 mice as a CLL model, we show that TCR-Vβ7+ NK1.1+ T cells...
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