Article
T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword.
Frontiers in immunology - 1 Jan 2020
Vlachonikola Elisavet, Stamatopoulos Kostas, Chatzidimitriou Anastasia
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is a malignancy of mature, antigen-experienced B lymphocytes. Despite great progress recently achieved in the management of CLL, the disease remains incurable, underscoring the need for further investigation into the underlying pathophysiology. Microenvironmental crosstalk has an established role in CLL pathogenesis and progression. Indeed, the malignant CLL cells are strongly...
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