Article
Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo.
Leukemia - 1 Mar 2016
Hanna B S, McClanahan F, Yazdanparast H, Zaborsky N, Kalter V, Rößner P M, Benner A, Dürr C, Egle A, Gribben J G, Lichter P, Seiffert M
Abstract excerpt
Chronic lymphocytic leukemia (CLL) is characterized by apoptosis resistance and a dysfunctional immune system. Previous reports suggested a potential role of myeloid cells in mediating these defects. However, the composition and function of CLL-associated myeloid cells have not been thoroughly investigated in vivo. Using the Eμ-TCL1 mouse model, we observed severe skewing of myeloid cell populations with CLL...
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