Article

Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors

2022-07-14

Abstract excerpt

<title>Abstract</title> <p>T-cell dysregulation in chronic lymphocytic leukemia (CLL) associates with low response rates to autologous T cell-based therapies. How CLL affects antigen-specific T-cell responses remains largely unknown. We investigated (epi)genetic and functional consequences of antigen-specific T-cell responses in presence of CLL <italic>in vitro</italic> and in an adoptive-transfer murine model. A...

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Literature Corpus work: 1d43b721-f3e1-591a-95c6-24a1a3af7c4b
DOI: 10.21203/rs.3.rs-1829072/v1

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