Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.

Oncotarget - 28 Jun 2016

Wu Jiazhu, Xu Xiaojing, Lee Eun-Joon, Shull Austin Y, Pei Lirong, Awan Farrukh, Wang Xiaoling, Choi Jeong-Hyeon, Deng Libin, Xin Hong-Bo, Zhong Wenxun, Liang Jinhua, Miao Yi, Wu Yujie, Fan Lei, Li Jianyong, Xu Wei, Shi Huidong

Abstract excerpt

Immunosuppression is a prevalent clinical feature in chronic lymphocytic leukemia (CLL) patients, with many patients demonstrating increased susceptibility to infections as well as increased failure of an antitumor immune response. However, much is currently not understood regarding the precise mechanisms that attribute to this immunosuppressive phenotype in CLL. To provide further clarity to this particular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Gene Expression Regulation, Leukemic

Share to Interleukin-2

Share to Jurkat Cells

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Treatment Outcome

Source

Open in PubMed Open full text

Identifiers

PMID: 27302925
DOI: 10.18632/oncotarget.9941
PMCID: PMC5130028

Genes

PDCD1
CCR6
KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic alteration of CD8+ T cells in chronic lymphocytic leukemia is associated with epigenetic reprogramming.PMID 27302925Read ↗

T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspectiveSemantic proximity Read ↗

Advances in epigenetic alterations of chronic lymphocytic leukemia: from pathogenesis to treatmentSemantic proximity Read ↗

Genetics and epigenetics of CLL.Semantic proximity Read ↗

Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectorsSemantic proximity Read ↗

T cells in chronic lymphocytic leukemia display dysregulated expression of immune checkpoints and activation markers.Semantic proximity Read ↗

Epigenetic modifications: Critical participants of the PD‑L1 regulatory mechanism in solid tumors (Review)Semantic proximity Read ↗

Targeting the PD-1/PD-L1 Signaling Pathway for Cancer Therapy: Focus on BiomarkersSemantic proximity Read ↗

Immunosuppressive Treg cells acquire the phenotype of effector-T cells in chronic lymphocytic leukemia patients.Semantic proximity Read ↗

Targeting the PD-1/PD-L1 Signaling Pathway for Cancer Therapy: Focus on BiomarkersSemantic proximity Read ↗

T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword.Semantic proximity Read ↗

B-cell–specific IRF4 deletion accelerates chronic lymphocytic leukemia development by enhanced tumor immune evasionSemantic proximity Read ↗

Expansion of a CD8(+)PD-1(+) replicative senescence phenotype in early stage CLL patients is associated with inverted CD4:CD8 ratios and disease progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.