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Article

Aspergillus fumigatus Intrinsic Fluconazole Resistance Is Due to the Naturally Occurring T301I Substitution in Cyp51Ap.

Antimicrobial agents and chemotherapy - 1 Sept 2016

Leonardelli Florencia, Macedo Daiana, Dudiuk Catiana, Cabeza Matias S, Gamarra Soledad, Garcia-Effron Guillermo

Abstract excerpt

Aspergillus fumigatus intrinsic fluconazole resistance has been demonstrated to be linked to the CYP51A gene, although the precise molecular mechanism has not been elucidated yet. Comparisons between A. fumigatus Cyp51Ap and Candida albicans Erg11p sequences showed differences in amino acid residues already associated with fluconazole resistance in C. albicans The aim of this study was to analyze the role of the...

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Source

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Identifiers

PMID: 27381395
DOI: 10.1128/AAC.00905-16
PMCID: PMC4997867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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