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Article

Insight into the Significance of Aspergillus fumigatus cyp51A Polymorphisms.

Antimicrobial agents and chemotherapy - 1 Jun 2018

Garcia-Rubio Rocio, Alcazar-Fuoli Laura, Monteiro Maria Candida, Monzon Sara, Cuesta Isabel, Pelaez Teresa, Mellado Emilia

Abstract excerpt

Triazole antifungal compounds are the first treatment choice for invasive aspergillosis. However, in the last decade the rate of azole resistance among Aspergillus fumigatus strains has increased notoriously. The main resistance mechanisms are well defined and mostly related to point mutations of the azole target, 14-α sterol demethylase (cyp51A), with or without tandem repeat integrations in the cyp51A promoter....

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Antifungal Agents
Aspergillus fumigatus
Cytochrome P-450 Enzyme System
Drug Resistance, Fungal
Fungal Proteins

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PMID: 29632011
DOI: 10.1128/AAC.00241-18
PMCID: PMC5971592

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