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Article

Molecular Confirmation of the Linkage between the Rhizopus oryzae CYP51A Gene Coding Region and Its Intrinsic Voriconazole and Fluconazole Resistance.

Antimicrobial agents and chemotherapy - 1 Aug 2018

Macedo Daiana, Leonardelli Florencia, Dudiuk Catiana, Theill Laura, Cabeza Matías S, Gamarra Soledad, Garcia-Effron Guillermo

Abstract excerpt

Rhizopus oryzae is the most prevalent causative agent of mucormycosis, an increasingly reported opportunistic fungal infection. These Mucorales are intrinsically resistant to Candida- and Aspergillus-active antifungal azole drugs, such as fluconazole (FLC) and voriconazole, respectively. Despite its importance, the molecular mechanisms of its intrinsic azole resistance have not been elucidated yet. The aim of...

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Identifiers

PMID: 29891608
DOI: 10.1128/AAC.00224-18
PMCID: PMC6105841

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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