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Article

CYP51C Y319H and H349R substitutions cannot confer azole resistance in Aspergillus flavus NRRL 3357-5.

Microbiology spectrum - 7 Jul 2026

Zhou Ya Bin, Grum-Grzhimaylo Alexey A, Meijer Martin, Kraak Bart, Houbraken Jos

Abstract excerpt

Azole antifungals inhibit the cytochrome P450-dependent lanosterol 14-α-demethylase (CYP51), an essential enzyme in the ergosterol biosynthetic pathway. While azole resistance mechanisms are well established in Aspergillus fumigatus, the molecular basis of resistance in Aspergillus flavus remains less defined. Previous studies identified nonsynonymous substitutions Y319H and H349R in CYP51C of azole-resistant A....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42262093
DOI: 10.1128/spectrum.00425-26
PMCID: PMC13339886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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