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Article

A Novel Y319H Substitution in CYP51C Associated with Azole Resistance in Aspergillus flavus.

Antimicrobial agents and chemotherapy - 1 Oct 2015

Paul R A, Rudramurthy S M, Meis J F, Mouton J W, Chakrabarti A

Abstract excerpt

This study aimed to explore any mutation in the CYP51 gene conferring azole resistance in Aspergillus flavus. Two voriconazole-resistant and 45 voriconazole-susceptible isolates were included in the study. Sequence analysis demonstrated a T1025C nucleotide change in CYP51C, resulting in the Y319H amino acid substitution in one resistant isolate. However, the earlier described T788G mutation in CYP51C conferring...

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Share to Antifungal resistance and susceptibility
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26248359
DOI: 10.1128/AAC.00637-15
PMCID: PMC4576050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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