Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicans

1 Jun 2022

Abstract excerpt

Background: Resistance to antifungal drugs for treating Candida infections remains a major concern globally despite the range of medications available. Most of these drugs target key proteins essential to the life cycle of the organism. An enzyme essential for fungal cell membrane integrity, lanosterol 14–α demethylase (CYP51), is encoded by the ERG11 gene in Candida species. This enzyme is the target of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Fungal Infections and Studies
Share to Probiotics and Fermented Foods

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35747333
DOI: 10.2147/idr.s360973

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A New Variant of Mutational and Polymorphic Signatures in the ERG11 Gene of Fluconazole-Resistant Candida albicansPMID 35747333Read ↗

Investigating role of positively selected genes and mutation sites of ERG11 in drug resistance of Candida albicans.Semantic proximity Read ↗

The new mutation L321F in Candida albicans ERG11 gene may be associated with fluconazole resistance.Semantic proximity Read ↗

Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida speciesSemantic proximity Read ↗

Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida SpeciesSemantic proximity Read ↗

Detection of ERG11 gene mutation in coding and non-coding region of clinical Candida glabrata (Nakaseomyces glabratu s) isolates from PakistanSemantic proximity Read ↗

In vitro fluconazole susceptibility of 1,903 clinical isolates of Candida albicans and the identification of ERG11 mutations.Semantic proximity Read ↗

Azole Resistance in Candida albicans Isolates from Oropharyngeal Candidiasis is Associated with ERG11 Mutation and Efflux OverexpressionSemantic proximity Read ↗

Overexpression of efflux pump transporter genes and mutations in ERG11 pave the way to fluconazole resistance in Candida tropicalis: A study from a North India region.Semantic proximity Read ↗

Relationship between antifungal resistance of fluconazole resistant Candida albicans and mutations in ERG11 gene.Semantic proximity Read ↗

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.Semantic proximity Read ↗

Susceptibility of clinical isolates of Candida species to fluconazole and detection of Candida albicans ERG11 mutationsSemantic proximity Read ↗

Mechanisms of azole antifungal resistance in clinical isolates of Candida tropicalisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.