Article

Analysis of Cyp51 protein sequences shows 4 major Cyp51 gene family groups across Fungi

2022-05-18

Abstract excerpt

Azole drugs target fungal sterol biosynthesis and are used to treat millions of human fungal infections each year. Resistance to azole drugs has emerged in multiple fungal pathogens including Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum , and Aspergillus fumigatus . The most well-studied resistance mechanism in A. fumigatus arises from missense mutations in the coding sequence combined with...

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Literature Corpus work: a22ea3fb-736a-5438-b768-f457b20cf9ad
DOI: 10.1101/2022.05.18.492509

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