Article
Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.
Nature communications - 5 Jul 2016
Cereda Matteo, Gambardella Gennaro, Benedetti Lorena, Iannelli Fabio, Patel Dominic, Basso Gianluca, Guerra Rosalinda F, Mourikis Thanos P, Puccio Ignazio, Sinha Shruti, Laghi Luigi, Spencer Jo, Rodriguez-Justo Manuel, Ciccarelli Francesca D
Abstract excerpt
Synchronous colorectal cancers (syCRCs) are physically separated tumours that develop simultaneously. To understand how the genetic and environmental background influences the development of multiple tumours, here we conduct a comparative analysis of 20 syCRCs from 10 patients. We show that syCRCs have independent genetic origins, acquire dissimilar somatic alterations, and have different clone composition. This...
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