Article

Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal Cancers

2024-10-14

Abstract excerpt

<title>Abstract</title> <p>Molecular characteristics of synchronous colorectal cancers (SCRCs) remain incompletely elucidated, despite their importance in targeted therapy selection. This retrospective study (2012–2014) compared the molecular characteristics and somatic mutations between SCRCs in 100 patients with surgically resected SCRCs. Molecular characteristics, including microsatellite instability (MSI) and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: befe4e90-5f9b-5fea-871f-be7377c1a5b0
DOI: 10.21203/rs.3.rs-4902441/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Molecular Mosaics: Unveiling Heterogeneity in Synchronous Colorectal CancersDOI 10.21203/rs.3.rs-4902441/v1Read

Genetic heterogeneity in synchronous colorectal cancers impacts genotyping approaches and therapeutic strategies.Semantic proximity Read

Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter studySemantic proximity Read

Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal cancer: a retrospective multicenter study.Semantic proximity Read

Clinicopathologic and molecular characteristics of synchronous colorectal cancers: heterogeneity of clinical outcome depending on microsatellite instability status of individual tumors.Semantic proximity Read

Whole exome sequencing reveals intertumor heterogeneity and distinct genetic origins of sporadic synchronous colorectal cancer.Semantic proximity Read

Molecular Typing and Clinical Characteristics of Synchronous Multiple Primary Colorectal CancerSemantic proximity Read

The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.Semantic proximity Read

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer.Semantic proximity Read

Clinicopathologic features of synchronous colorectal carcinoma: A distinct subset arising from multiple sessile serrated adenomas and associated with high levels of microsatellite instability and favorable prognosis.Semantic proximity Read

Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes.Semantic proximity Read

Next-Generation Sequencing-Based Analysis of the Genetic Mutation Spectrum in Colorectal Cancer: A Large Single‑Center Study From Southeast China With Cross‑Population Comparison.Semantic proximity Read

Intra-tumor genetic heterogeneity in rectal cancer.Semantic proximity Read