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Article

Quantitative trait locus mapping methods for diversity outbred mice.

G3 (Bethesda, Md.) - 18 Sept 2014

Gatti Daniel M, Svenson Karen L, Shabalin Andrey, Wu Long-Yang, Valdar William, Simecek Petr, Goodwin Neal, Cheng Riyan, Pomp Daniel, Palmer Abraham, Chesler Elissa J, Broman Karl W, Churchill Gary A

Abstract excerpt

Genetic mapping studies in the mouse and other model organisms are used to search for genes underlying complex phenotypes. Traditional genetic mapping studies that employ single-generation crosses have poor mapping resolution and limit discovery to loci that are polymorphic between the two parental strains. Multiparent outbreeding populations address these shortcomings by increasing the density of recombination...

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Identifiers

PMID: 25237114
DOI: 10.1534/g3.114.013748
PMCID: PMC4169154

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