Article
A high-resolution association mapping panel for the dissection of complex traits in mice.
Genome research - 1 Feb 2010
Bennett Brian J, Farber Charles R, Orozco Luz, Kang Hyun Min, Ghazalpour Anatole, Siemers Nathan, Neubauer Michael, Neuhaus Isaac, Yordanova Roumyana, Guan Bo, Truong Amy, Yang Wen-pin, He Aiqing, Kayne Paul, Gargalovic Peter, Kirchgessner Todd, Pan Calvin, Castellani Lawrence W, Kostem Emrah, Furlotte Nicholas, Drake Thomas A, Eskin Eleazar, Lusis Aldons J
Abstract excerpt
Systems genetics relies on common genetic variants to elucidate biologic networks contributing to complex disease-related phenotypes. Mice are ideal model organisms for such approaches, but linkage analysis has been only modestly successful due to low mapping resolution. Association analysis in mice has the potential of much better resolution, but it is confounded by population structure and inadequate power to...
Topics
Join the communities discussing this publication.