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Article

Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies.

PLoS genetics - 1 Feb 2026

Mullis Martin N, Lefebvre Austin E Y T, Sivasubramanian Kathyayini, Luo Angela, Schmid Florian, Sooknah Matt, Wright Kevin M, Raj Anil, Zavala-Solorio José, Zhang Chunlian, Riegler Johannes, Gillich Astrid, Ruby J Graham

Abstract excerpt

Diversity Outbred (DO) mice are a powerful model system for mapping complex traits due to their high genetic diversity and mapping resolution. However, while there are extensive tools available for standard genetic analysis in DO mice, fewer techniques have been implemented to facilitate integrated, cross-study analysis. Here, we implement Haseman-Elston regression to estimate genetic correlations among 7,233...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41758904
DOI: 10.1371/journal.pgen.1012037
PMCID: PMC12948109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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