Article
Low-coverage whole-genome sequencing facilitates accurate and cost-effective haplotype reconstruction in complex mouse crosses.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2025
Widmayer Samuel J, Wooldridge Lydia K, Swanzey Emily, Barter Mary, Snow Chrystal, Saul Michael, Meng Qingchang, Dumont Beth, Reinholdt Laura, Gatti Daniel M
Abstract excerpt
The search for the underlying genetic contributions to complex traits and diseases relies on accurate genetic data from populations of interest. Outbred populations, like the Diversity Outbred (DO), are commonly genotyped using commercial SNP arrays, such as the Giga Mouse Universal Genotyping Array (GigaMUGA). However, array genotypes are expensive to collect, subject to significant ascertainment bias, and too...
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