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Article

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility.

G3 (Bethesda, Md.) - 4 Jan 2022

Zou Jennifer, Gopalakrishnan Shyam, Parker Clarissa C, Nicod Jerome, Mott Richard, Cai Na, Lionikas Arimantas, Davies Robert W, Palmer Abraham A, Flint Jonathan

Abstract excerpt

Combining samples for genetic association is standard practice in human genetic analysis of complex traits, but is rarely undertaken in rodent genetics. Here, using 23 phenotypes and genotypes from two independent laboratories, we obtained a sample size of 3076 commercially available outbred mice and identified 70 loci, more than double the number of loci identified in the component studies. Fine-mapping in the...

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Identifiers

PMID: 34791208
DOI: 10.1093/g3journal/jkab394
PMCID: PMC8728023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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