Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR

4 Jul 2016

Abstract excerpt

Oestrogen receptor α (ERα) antagonists are used in endocrine therapies for ERα-positive (ERα+) breast cancer patients. Unfortunately the clinical benefit is limited due to intrinsic and acquired drug resistance. Here using integrated genomic and functional studies, we report that amplification and/or overexpression of COPS5 (CSN5/JAB1) confers resistance to tamoxifen. Amplification and overexpression of COPS5, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Estrogen and related hormone effects
Share to Peptidase Inhibition and Analysis
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27375289
DOI: 10.1038/ncomms12044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoRPMID 27375289Read ↗

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer ProgressionSemantic proximity Read ↗

The Emerging Role of the COP9 Signalosome in CancerSemantic proximity Read ↗

Targeted inhibition of the COP9 signalosome for treatment of cancerSemantic proximity Read ↗

The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers.Semantic proximity Read ↗

A novel ARMC5-containing ubiquitin ligase controls the degradation of HSPA1A and its client protein estrogen receptor alphaSemantic proximity Read ↗

Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanismsSemantic proximity Read ↗

MYSM1 co-activates ERα action via histone and non-histone deubiquitination to confer antiestrogen resistance in breast cancerSemantic proximity Read ↗

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancersSemantic proximity Read ↗

Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.Semantic proximity Read ↗

The C-terminal tail of CSNAP attenuates the CSN complex.Semantic proximity Read ↗

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.Semantic proximity Read ↗

Mammalian COP9 signalosomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.