Article
The Estrogen Receptor Cofactor SPEN Functions as a Tumor Suppressor and Candidate Biomarker of Drug Responsiveness in Hormone-Dependent Breast Cancers.
Cancer research - 15 Oct 2015
Légaré Stéphanie, Cavallone Luca, Mamo Aline, Chabot Catherine, Sirois Isabelle, Magliocco Anthony, Klimowicz Alexander, Tonin Patricia N, Buchanan Marguerite, Keilty Dana, Hassan Saima, Laperrière David, Mader Sylvie, Aleynikova Olga, Basik Mark
Abstract excerpt
The treatment of breast cancer has benefitted tremendously from the generation of estrogen receptor-α (ERα)-targeted therapies, but disease relapse continues to pose a challenge due to intrinsic or acquired drug resistance. In an effort to delineate potential predictive biomarkers of therapy responsiveness, multiple groups have identified several uncharacterized cofactors and interacting partners of ERα,...
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