Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers

16 Feb 2011

Abstract excerpt

The mammalian constitutive photomorphogenesis 9 (COP9) signalosome (CSN), a protein complex involved in embryonic development, is implicated in cell cycle regulation and the DNA damage response. Its role in tumor development, however, remains unclear. Here, we have shown that the COP9 subunit 6 (CSN6) gene is amplified in human breast cancer specimens, and the CSN6 protein is upregulated in human breast and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to RNA modifications and cancer
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21317535
DOI: 10.1172/jci44111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancersPMID 21317535Read ↗

The Emerging Role of the COP9 Signalosome in CancerSemantic proximity Read ↗

Mammalian COP9 signalosomeSemantic proximity Read ↗

14-3-3σ Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 StabilitySemantic proximity Read ↗

Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development.Semantic proximity Read ↗

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer ProgressionSemantic proximity Read ↗

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.Semantic proximity Read ↗

The COP9 Signalosome Regulates Skp2 Levels and Proliferation of Human CellsSemantic proximity Read ↗

Role of the COP1 protein in cancer development and therapy.Semantic proximity Read ↗

Molecular characterization of subunit 6 of the COP9 signalosome and its role in multifaceted developmental processes in Arabidopsis.Semantic proximity Read ↗

Combined Kdm6a and Trp53 Deficiency Drives the Development of Squamous Cell Skin Cancer in Mice.Semantic proximity Read ↗

Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathySemantic proximity Read ↗

TRIM8 modulates p53 activity to dictate cell cycle arrestSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.