Article

Targeting the COP9 signalosome overcomes platinum resistance in ovarian cancer through two distinct genome stability mechanisms

2025-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Tubo-ovarian high-grade serous carcinoma (HGSC) is a leading cause of gynecologic cancer mortality, largely due to the emergence of platinum resistance, which serves as the mainstay of chemotherapy. Here, we identify COPS5 as a therapeutic target and use an available small molecule inhibitor to overcome platinum resistance. A genetic screen for platinum-induced DNA damage in a platinum resistant...

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Literature Corpus work: 043f11fa-e931-5587-9d1e-a5cd9445d418
DOI: 10.1101/2025.08.04.668450

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