Article

A novel ARMC5-containing ubiquitin ligase controls the degradation of HSPA1A and its client protein estrogen receptor alpha

2026-02-22

Abstract excerpt

<title>Abstract</title> <p> ARMC5 is the substrate recognition subunit of a recently discovered multiple-subunit ubiquitin ligase (ARMC5-E3), which is composed of ARMC5, cullin3, and RBX1. ARMC5-E3 is the major E3 for RNA polymerase II. ARMC5 interacts with multiple heat shock proteins, but the biological significance of these interactions is not known. We discovered that HSPA1A and its client protein, estrogen...

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Literature Corpus work: 273cd0c6-9759-5f0b-a416-2125dc3bdb52
DOI: 10.21203/rs.3.rs-8810312/v1

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