Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression

15 Jan 2008

Abstract excerpt

CSN5 has been implicated as a candidate oncogene in human breast cancers by genetic linkage with activation of the poor-prognosis, wound response gene expression signature. CSN5 is a subunit of the eight-protein COP9 signalosome, a signaling complex with multiple biochemical activities; the mechanism of CSN5 action in cancer development remains poorly understood. Here, we show that CSN5 isopeptidase activity is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Peptidase Inhibition and Analysis
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18199546
DOI: 10.1158/0008-5472.can-07-3060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer ProgressionPMID 18199546Read ↗

The Emerging Role of the COP9 Signalosome in CancerSemantic proximity Read ↗

COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoRSemantic proximity Read ↗

Targeted inhibition of the COP9 signalosome for treatment of cancerSemantic proximity Read ↗

Mammalian COP9 signalosomeSemantic proximity Read ↗

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.Semantic proximity Read ↗

Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancersSemantic proximity Read ↗

The pivotal oncogenic role of Jab1/CSN5 and its therapeutic implications in human cancerSemantic proximity Read ↗

The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.Semantic proximity Read ↗

The C-terminal tail of CSNAP attenuates the CSN complex.Semantic proximity Read ↗

The COP9 Signalosome Regulates Skp2 Levels and Proliferation of Human CellsSemantic proximity Read ↗

Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia.Semantic proximity Read ↗

Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.