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Article

COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.

Development (Cambridge, England) - 15 Jul 2017

Suisse Annabelle, He DanQing, Legent Kevin, Treisman Jessica E

Abstract excerpt

The COP9 signalosome removes Nedd8 modifications from the Cullin subunits of ubiquitin ligase complexes, reducing their activity. Here, we show that mutations in the Drosophila COP9 signalosome subunit 1b (CSN1b) gene increase the activity of ubiquitin ligases that contain Cullin 1. Analysis of CSN1b mutant phenotypes revealed a requirement for the COP9 signalosome to prevent ectopic expression of Epidermal...

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Identifiers

PMID: 28619822
DOI: 10.1242/dev.148767
PMCID: PMC5536928

Genes

EGFR
SKP1

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COP9 signalosome subunits protect Capicua from MAPK-dependent and -independent mechanisms of degradation.PMID 28619822Read ↗

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The C-terminal tail of CSNAP attenuates the CSN complex.Semantic proximity Read ↗

The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p.Semantic proximity Read ↗

Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.Semantic proximity Read ↗

Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development.Semantic proximity Read ↗

Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.Semantic proximity Read ↗

Genomic analysis of COP9 signalosome function in Drosophila melanogaster reveals a role in temporal regulation of gene expression.Semantic proximity Read ↗

The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis.Semantic proximity Read ↗

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