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Article

Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer.

Cell reports - 9 Mar 2021

Yang Yongguang, Leonard Marissa, Luo Zhenhua, Yeo Syn, Bick Gregory, Hao Mingang, Cai Chunmiao, Charif Mahmoud, Wang Jiang, Guan Jun-Lin, Lower Elyse E, Zhang Xiaoting

Abstract excerpt

MED1 (mediator subunit 1) co-amplifies with HER2, but its role in HER2-driven mammary tumorigenesis is still unknown. Here, we generate MED1 mammary-specific overexpression mice and cross them with mouse mammary tumor virus (MMTV)-HER2 mice. We observe significantly promoted onset, growth, metastasis, and multiplicity of HER2 tumors by MED1 overexpression. Further studies reveal critical roles for MED1 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33691110
DOI: 10.1016/j.celrep.2021.108822
PMCID: PMC8050805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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