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Targeted inhibition of the COP9 signalosome for treatment of cancer

24 Oct 2016

Abstract excerpt

The COP9 signalosome (CSN) is a central component of the activation and remodelling cycle of cullin-RING E3 ubiquitin ligases (CRLs), the largest enzyme family of the ubiquitin-proteasome system in humans. CRLs are implicated in the regulation of numerous cellular processes, including cell cycle progression and apoptosis, and aberrant CRL activity is frequently associated with cancer. Remodelling of CRLs is...

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PMID: 27774986
DOI: 10.1038/ncomms13166

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