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Article

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

1 Jul 2016

Abstract excerpt

Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. This population, marked by high levels of EpCAM and CD24, is also prevalent in human primary SCLC tumors. Murine SCLC TPCs are numerous and highly proliferative but not...

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PMID: 27373157
DOI: 10.1016/j.celrep.2016.06.021

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